Photo by Linda Cronan

Medical Center District holiday rentals

We found 210 holiday rentals — enter your dates for availability

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August 2025

September 2025

Find the perfect place for you stay in Medical Center District by choosing from 51 houses, 25 apartments and other holiday rentals. Holiday rentals offer the amenities that you expect for you and your friends, family or even pets, such as cable TV and a washer and dryer. You'll be able to choose a property to rent for everyone's needs, including places that are non-smoking or accessible.

Holiday rentals with weekly discounts - Medical Center District

Showing deals for:14 Nov - 21 Nov

Exceptional

(9 reviews)

CYC Mega House with BBQ Gazebo

San Antonio, TX

8% off

AU$2,002 per night

includes taxes & fees

Exceptional

(45 reviews)

Peaceful Garden House on 5-Acre Nature Estate in The Heart of San Antonio

San Antonio, TX

7% off

AU$564 per night

includes taxes & fees

Exceptional

(8 reviews)

Director's Cut - A Birdy Vacation Rental

San Antonio, TX

7% off

AU$568 per night

includes taxes & fees

Wonderful

(12 reviews)

Cheerful 3-bedroom Home with a Pool! And Game room. North central!

San Antonio, TX

7% off

AU$343 per night

includes taxes & fees

Exceptional

(181 reviews)

Amazing & Comfortable B&B, Rustic & Inviting Feel, NEW BIG A/C Unit and more

San Antonio, TX

15% off

AU$207 per night

includes taxes & fees

Wonderful

(35 reviews)

Medical Center Condo for Medical Students, Professionals and Small Families.

San Antonio, TX

7% off

AU$229 per night

includes taxes & fees

Exceptional

(78 reviews)

5-Acre Nature Retreat In The Heart Of San Antonio with Pickleball and Tennis

San Antonio, TX

11% off

AU$831 per night

includes taxes & fees

Wonderful

(87 reviews)

The Peacock House for animal lovers. Prime location! Near main attractions.

San Antonio, TX

7% off

AU$269 per night

includes taxes & fees

Exceptional

(13 reviews)

Amazing, Contemporary, Beautiful, Peaceful, and Perfectly Located Property

San Antonio, TX

7% off

AU$235 per night

includes taxes & fees

Find spaces that suit your style

House

Condo/Apartment

Cabin

Cottage

Villa

Find the best place to stay - Medical Center District

Cozy, Family Friendly Home near Sea World, Fiesta Tx, Med Ctr & BMT.

Sleeps 12 · 3 bedrooms · 2 bathrooms

Tower Point - A Birdy Vacation Rental

Sleeps 6 · 2 bedrooms · 2 bathrooms

Very airy living and dining area with views through french doors to back patio.

Bright Spacious Comfort Medical Center

Sleeps 8 · 2 bedrooms · 2 bathrooms

Modern Comfort: 1 BR/ Medical Center/Resort Style

Sleeps 4 · 1 bedroom · 1 bathroom

Medical Center Condo for Medical Students, Professionals and Small Families.

Sleeps 4 · 1 bedroom · 1 bathroom

Peace of mind
Our Book with Confidence Guarantee gives you 24/7 support
More quality time
From booking to staying, the whole process is simple and enjoyable
All the privacy of home
Enjoy full kitchens, laundry, pools, gardens and more
More for less
More space, more privacy, more amenities — more value

Frequently asked questions

What is the most popular type of holiday home accommodation in Medical Centre District?

Based on our data, houses are considered the most popular type of holiday home in Medical Centre District. But as you know, everyone's idea of an epic trip is bound to be different. Stayz has holiday homes of all shapes and sizes, and we'll help you discover your perfect match.

How much does it cost to rent a holiday home in Medical Centre District?

Length of stay, season and property type are among the factors that can determine the price of a holiday home. Simply enter your travel dates to find the ultimate escape. From cosy country cottages to sprawling luxury villas, all Stayz holiday homes provide unbeatable value.

How much does it cost to rent a beach house in Medical Centre District?

When you travel and the size and style of the property will determine the cost of your beachside stay. Put in your Medical Centre District travel dates to see your options on Stayz. Can't live without a hot tub? Use the filters to select the amenities and features you want in your holiday home.

Are there pet-friendly holiday homes in Medical Centre District?

Pack up a suitcase for your puppy dog because Medical Centre District has four stays that roll out the welcome mat to pets. Let your four-legged pal enjoy the family fun at one of our pet-friendly holiday homes on Stayz. Simply enter your dates then check the "Pets allowed" filter box.

Can I rent a house with a pool in Medical Centre District?

Tick the "pool" box in our filter tool and you can choose from two houses with private pools in Medical Centre District on Stayz. Morning swim, afternoon splash or midnight soak? Leisure time is up to you when your holiday property has a swimming pool.

What are popular home amenities in Medical Centre District?

The most popular home amenities people look for in Medical Centre District include a swimming pool, nearby museums and a barbecue grill. Whether you're on a trip with buddies, family or even pets, Stayz holiday homes have the best amenities for chilling out with the people you cherish the most.

Are there holiday homes in Medical Centre District that welcome kids?

Bring the entire group together for an adventure in Medical Centre District at one of our four family-friendly properties. Many of these stays come with conveniences that are great for trips with the kids, like laundries, living rooms and entertainment units. Simply click on the "Properties good for families" filter box and choose your favourite.

What are the top attractions for families in Medical Centre District?

Keeping the kiddos entertained during your holiday in Medical Centre District is a cinch with these leading family-friendly attractions:

Six Flags Fiesta Texas
San Antonio SeaWorld
San Antonio Zoo and Aquarium

Can I find two-bedroom holiday homes in Medical Centre District?

You can select from two two-bedroom homes in Medical Centre District. Settle the kids into the second room or fill it with a couple of your best buddies. There's a comfy spot for whoever's lucky enough to be joining your journey.

How can I find holiday homes with air conditioning in Medical Centre District?

You'll have your pick of four holiday homes with air conditioning in Medical Centre District offering that gentle, cool breeze and extra touch of comfort. Simply enter your desired travel dates and then make use of our filter tool to find properties with air conditioning.

How old do you have to be to rent a holiday home in Medical Centre District?

The minimum age allowed can vary across properties on Stayz, so be sure to look at the rules of the holiday home in Medical Centre District you want to book. But typically, it's 16, 18 or 21.

How long can I rent a holiday home in Medical Centre District for?

The amount of time you can rent a Medical Centre District holiday home for is down to each property. Simply enter your preferred travel dates to browse available options offering extended stays. They come with the things you need to make your extended trip more convenient and comfortable, like kitchens and yards. Some holiday homes might also offer weekly or monthly discounted prices, so you can hang around longer for less.